基于晶振谐振驱动的电容式液面探测系统研究
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1.浙江大学生物医学工程与仪器科学学院杭州310027; 2.嘉兴凯实生物科技股份有限公司嘉兴314000

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TH77

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国家自然科学基金(22427806)项目资助


Design of a crystal oscillation-based capacitive liquid level detection system
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1.College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027,China; 2.Quaero Life Science Co., Ltd., Jiaxing 314000, China

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    摘要:

    液面探测是全自动体外诊断设备中的关键环节,其准确性直接关系到试剂吸取安全与检测结果可靠性。面向接触式液面探测的精度与稳定性需求,设计了一种基于晶振法的电容式液面探测系统。该系统采用晶体振荡器产生高稳定度的正弦激励信号,驱动电容分压电路工作;当探测探针接触液面时,其寄生电容的变化将调制激励信号的幅值。通过同步选频峰值检测与自稳定脉冲转换机制,实现对液面位置的高灵敏度、高稳定性探测。基于所建立的等效电容模型及传递函数分析,对系统中关键元器件参数进行了优化配置。在Simulink仿真中,验证了前端电路具备150 μs的响应延迟特性,并确认自稳定电路在输入电压变化量ΔV>15 mV或变化斜率>1 V/ms时呈现出脉冲饱和特性,从而保证系统在复杂工况下的稳定性。结果表明去离子水因具有较高阻抗,导致输出脉冲幅值相较于生理盐水有所下降;而当盐水浓度超过0.9%后,脉冲幅值随浓度增加呈现非线性饱和趋势。系统在100~5 000 μL液位范围,测量标准差≤50 μm,变异系数(CV)≤0.75%;在连续10 000次测试中,相邻两次测量偏差稳定在±0.15 mm范围。液位高度的微小线性下降主要由液体蒸发及探针壁面残留引起。通过晶体振荡器在谐振点的工作模式与关键参数的协同优化,实现了医疗设备级的检测精度与长期运行可靠性,为生化分析仪、免疫分析仪、尿液分析仪等体外诊断设备提供了切实可行的工程化解决方案。

    Abstract:

    Liquid-level detection is a critical function in fully automated in vitro diagnostic devices, as its accuracy is directly related to reagent aspiration safety and the reliability of test results. Targeting the requirements for precision and stability in contact-based liquid-level detection, this study designs a crystal-oscillator-based capacitive liquid-level detection system. A crystal oscillator is used to generate a highly stable sinusoidal excitation signal that drives a capacitive voltage divider, When the sensing probe contacts the liquid surface, variations in its parasitic capacitance modulate the amplitude of the excitation signal. By combining synchronous band-selective peak detection with a self-stabilizing pulse conversion mechanism, the system achieves highly sensitive and stable detection of the liquid level. Based on an equivalent capacitance model and transfer function analysis, the key component parameters in the system are optimally configured. Simulink simulations verify that the front-end circuit exhibits a response delay of 150 μs and confirm that the self-stabilizing circuit enters a pulse saturation state when the input voltage variation ΔV > 15 mV or the slew rate > 1 V/ms, thereby ensuring system stability under complex operating conditions. Experimental results show that, due to its higher impedance, deionized water produces a lower output pulse amplitude than physiological saline. When the saline concentration exceeds 0.9%, the pulse amplitude exhibits a nonlinear saturation trend with increasing concentration. Within a liquid volume range of 100~5 000 μL, the system achieves a measurement standard deviation ≤ 50 μm and a coefficient of variation (CV) ≤ 0.75%. Over 10 000 consecutive tests, the deviation between two adjacent measurements remains within ±0.15 mm. The slight linear decrease in liquid level is mainly attributed to liquid evaporation and residual adhesion on the probe wall. By operating the crystal oscillator at its resonant point and jointly optimizing the key parameters, the proposed design achieves medical-device-grade detection accuracy and long-term operational reliability, providing a practical and engineering-ready solution for liquid handling in biochemical analyzers, immunoassay analyzers, urinalysis analyzers, and other in vitro diagnostic instruments.

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张桢阳,江星宇,黄鹤,李向坤,田良飞.基于晶振谐振驱动的电容式液面探测系统研究[J].仪器仪表学报,2025,46(11):322-331

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  • 在线发布日期: 2026-02-09
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