In response to the common problems of long response time, poor temperature measurement accuracy, and high radiation error of temperature sensors used in high-altitude detection, a temperature sensor with small packaging volume, fast response speed, strong radiation resistance is developed. Mn-Ni-Cu-Fe-O-based chip thermistors with dimensions of 0. 4 mm×0. 4 mm×0. 25 mm and 0. 6 mm× 0. 6 mm×0. 25 mm are prepared by the solid-phase method. On the sensitive surface of the chip thermistor, an insulation film and an aluminum metal reflector film are deposited sequentially. The results show that the resistance range of the developed thermistor is 1 000~ 4. 2 kΩ and 375 ~ 1. 6 kΩ in the temperature range of - 80℃ to 60℃ . Thermal dissipation and response speed tests are conducted on the thermistor, and the results show a thermal dissipation coefficient of 1. 034 mW/ ℃ and a response time of 0. 63 s for the developed sensor. The temperature measurement error of the thermistor is studied by using a solar simulator, and the minimum temperature measurement error is 0. 22℃ under an irradiance intensity of 100 W/ m 2 . The thermistor has the potential to be used in the sounding instrument of high-altitude meteorological detection.