With the continuous fusion and optimization of multi-link, multi-equipment manufacturing process and information in the current intelligent manufacturing scenarios of aviation, aerospace and large scientific instruments, the demand for distance measurement is being promoted from the traditional local, single-parameter, off-line and time-sharing to the global, multi-objective online, real-time and synchronous. The existing laser ranging methods are limited by principle and face bottlenecks in precision, real-time performance and parallel capability. This article develops a dual-femtosecond laser multi-target absolute distance measurement system based on the time-of-flight method. A specific fiber beam splitting scheme is designed to make femtosecond laser pulses reach multiple targets at the same time. Multiple sets of pulses with distinguished feature matching in the temporal domain are constructed. The pulses carrying distance information are transferred into the FPGA data processing unit after the intensity cross-correlation module, and the real-time multiple absolute distances and realizing the integrated design of the whole system are calculated. Finally, the system for verification and the experiment results show that the ranging accuracy of the system is better than 4 μm and the allen deviation is better than 10 -5 m at the updating speed of 2 kHz. On this basis, the parallel optical path structure is established to realize the simultaneous measurement of multiple degrees of freedom, and the measurement deviation is better than 5″.