The space pointing determination technology is a basic and key technique in aerospace development. Orbital multi-physics field has distributed-parameterized, strong time-variant, and inter-coupling features, which has become the major obstacle for significant advances in measurement accuracy level. In this article, we firstlyintroduce the complex effects of space multi-physics fields. Then, the research status of multi-physics field error is summarized from threeaspects of analysis and suppression methods, on-ground and on-orbit calibration consist of the facilities and key technologies. By accurately simulating and measuring the multi-physics field as orbital environment,and creating an innovative milliarcsecond space pointing calibration system, the infinitesimal error sources caused by space multi-physics field can be unambiguously identified,the inner coupling mechanism of space multi-physics field can be revealed and the theoretical blank in space complex environment effects on pointingdetermination can be compensated. In this way, the space pointing measurement accuracy is pushed to milliarcsecond level. Finally, some suggestions and prospects are given based on the key problems in the research and engineering implementation of space multi-physics field effects.