The current clinical orthodontic treatment process mainly relies on the doctors′ experience. It is difficult to quantify the magnitude of the applied orthodontic force. The Omega-loop bent at the end of the orthodontic archwire can realize the effect of continuous and multiple reloading on the vertical-closure-loop bent at the same orthodontic archwire. Thus, this can reduce the clinical treatment time, and improve the efficiency of orthodontic treatment. The aim of this study is to quantify the orthodontic force generated by combining vertical closure and Omega loop orthodontic archwire. The force characteristics of the one-wire multi-loop combination orthodontic archwire is analyzed, and the orthodontic force is established by using the principle of beam micro-deformation and the principle of interaction force. The influence of bending parameters of the one-wire multi-loop combination orthodontic archwire on the orthodontic force is investigated. By formulating a 3D model of the one-wire multi-loop combination orthodontic archwire and an experimental platform for orthodontic force measurement, the finite element simulation analysis and experimental measurements are performed. The correlation analysis is conducted between the calculated data obtained from the mechanical model and the simulation data obtained from the simulation analysis and the experimental data obtained from the orthodontic force measurement experiment based on the one-dimensional force sensor. The correlation coefficient is ξT≥ 98. 192% between the calculated and the experimental data, and the correlation coefficient is ξA ≥ 97. 34% between the simulated and the experimental data. The accuracy and the reliability of the mechanical model, the simulation model and the simulation process are evaluated. The mechanical model and simulation model can assist physicians to design the personalized orthodontic archwire safely and efficiently. It provides theoretical basis for effective orthodontic treatment and further lays the foundation for clinical personalized and digital orthodontic treatment.