Based on the McClements model for the analysis of acoustic propagation in two-phase flow of suspended masses, the effects of solid phase concentration, particle size and ultrasonic frequency on the acoustic attenuation coefficient in suspended mass solutions are investigated by numerical simulation. Among them, the 0. 5th power of ultrasonic frequency and the solid phase concentration have the positive correlation with the attenuation coefficient, respectively. The solid phase particle size and the attenuation coefficient have a negative correlation with the first order. The relative error between the inverse model and the McClements model is less than 2% . An experimental system is established to measure the attenuation coefficient and concentration of the suspension solution, and experiments are implemented to measure the solid-phase concentration under the conditions of particle size r = 75 μm and ultrasonic frequency of 700 kHz and 1. 1 MHz, respectively. Experimental results show that the maximum relative error between the concentration values deduced from the inverse model and the actual set concentration is 11. 2% ( 700 kHz) and 9. 6% ( 1. 1 MHz). The inverse model constructed in this article can provide some theoretical reference for the study of suspension concentration measurement equipment.