Liquid-solid two-phase flow is widely used in energy, petrochemical and other industrial processes. The pressure drop of twophase flow is an important flow parameter which is helpful for flow modeling and analysis. A liquid-solid two-phase pressure drop measurement model is formulated. An ultrasonic-based liquid-solid two-phase pressure drop measurement method is proposed, which combines the ultrasound Doppler and ultrasound transmission attenuation. A liquid-solid two-phase flow experiment platform is established to study the law of two-phase pressure drop. As the two-phase mixing flow rate and the solid phase volume fraction increase, the pressure drop of the liquid-solid two phases gradually increases. When the solid phase volume fraction is 0. 28% ~ 1. 37% and the two-phase mixing flow rate is 0. 9~ 1. 65 m/ s, the average relative errors between the two-phase pressure drop measured by the liquidsolid two-phase pressure drop measurement model and the Churchill model using the ultrasound method and the pressure drop measured by the differential pressure sensor are 4. 93% and 5. 10% , respectively. These results show the accuracy of the measurement model. The pressure drop measurement for the two-phase heterogeneous flow is carried out and it further broadens the application range of the pressure drop measurement model. This research work provides a basic method for non-invasive ultrasound measurement of liquid-solid two-phase pressure drop.