In order to detect isopropanol gas harmful to human health, a high sensitive isopropanol gas sensor based on In2O3 and Fe2O3 loaded In2O3(Fe2O3@ In2O3 ) hollow sphere was successfully prepared. The crystal phase, morphology and chemical composition of the prepared In2O3 and Fe2O3@ In2O3 sample were analyzed with characterization methods. The experiment test results show that the hollow sphere gas sensor of Fe2O3 @ In2O3 has better gas-sensing characteristics to isopropanol than pure In2O3 under the optimal operating temperature of 200℃ . The response value of the hollow sphere gas sensor of Fe2O3@ In2O3 can reach 28. 2 (which is 1. 75 times that of pure phase In2O3 ), and the response time and recovery time are 1 s and 2 s, respectively, the gas sensor also has good repeatability and stability. An n-n heterojunction is formed between the two oxides of Fe2O3 and In2O3 , which increases the initial resistance of the sensor, thereby optimizes the gas-sensing characteristics of In2O3 . The prepared hollow sphere gas sensor of Fe2O3@ In2O3 has a wide application prospect in detecting isopropanol gas.