Research on key techniques for measuring the ratio of urine albumin to urine creatinine
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R318. 6 TP212. 3 TH741

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    Abstract:

    Related studies show that about 8% of the global population suffer from chronic kidney disease (CKD). The prevalence is on the rise and the patients are getting younger. According to the principle of Lambert-Beer law, the urine albumin is detected by the immune-transmission turbidimetric method, aiming at the characteristic of antigen-antibody conjugate forming antigen-antibody conjugate precipitate from the liquid phase. The renal health of the patients is evaluated by measuring urinary creatinine and calculating the ratio of urinary albumin to urinary creatinine. The experimental device is set up to carry out clinical comparative experiments with HITACHI 7180 automatic biochemical analyzer. Experimental results show that the coefficient of determination for linear fitting of urinary albumin is r 2 = 0. 996, and the coefficient of repeatability variation is CV ≤4. 087% . Compared with the HITACHI 7180 automatic biochemical analyzer, the positive and negative albumin detection coincidence rates are 89. 36% and 92. 06% , respectively. The ratios of urinary albumin to urinary creatinine is 92. 96% positive and 87. 18% negative.

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  • Received:
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  • Online: June 28,2023
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