The process of zinc coating weight control has the characteristics of nonlinear and multivariable. A new simulation and optimization analysis method is proposed to control the influence factors of zinc coating weight control, which is based on orthogonal experimental design, numerical simulation and response surface method. The hot galvanizing production process with the weight of single surface galvanizing layer between 100 and 400 g/m2 is taken as the research object. Orthogonal experimental and online data collection methods are used to collect sample data. The importance of each factor on the response index is ranked by range analysis. Based on the experimental results, the linear regression formula is derived and the orthogonal experiment with interaction columns is used to analyze the influence of factor interaction on the model. In this way, experimental results can be modified. Results show that the multiple correlation coefficient of the fitted quadratic regression equation model is R2=0997 6 and P<0000 1. According to the experimental results, the factors influencing the weight change of zinc coating is ranked as the order of jet pressure, strip velocity, interaction between jet pressure and strip velocity, nozzle distance, nozzle gap, and interaction between jet pressure and nozzle distance.