In order to solve the selfpowering problem of wireless sensors in intelligent wheels, a piezoelectric selfpowered intelligent wheel is proposed, which enhances the practicality and safety of existing wheel energy harvesting technology. The piezoelectric cantilever beam is fixed in the spoke, which generates periodic excitation with the gravity effect of the free end mass block in rotation. In order to avoid direct collision with the spoke, a safety limiting structure is designed. Through establishing the electromechanical dynamics model of the system, the parameters of the device are designed for the R16sized rim. An experiment platform was built to achieve the load optimization and study the influence of the limiting pitch on the harvesting performance. In order to fully evaluate the performance of the piezoelectric selfpowered intelligent wheel, a prototype experiment was carried out on a real vehicle. The results show that the harvesting device designed in this paper can obtain the energy of 643~8660 μW at 50~70 km/h, which provides the possibility of establishing a selfpowered intelligent wheel system without maintenance.