面向神经血动力与电生理监测的一体化fNIRS-EEG成像系统
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天津大学精密仪器与光电子工程学院天津300072

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TH773

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国家自然科学基金(62075156,62205239)、中国博士后自然科学基金(2023M732600)项目资助


Integrated neurohemodynamics and electrophysiology imaging system for activation monitoring in daily situations
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College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China

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    摘要:

    近年来,功能性近红外光谱成像(fNIRS)和脑电图(EEG)已经广泛应用于建立自然和社会交互场景下的神经认知响应与精神状态的脑功能测量与分析。尽管已有一些 fNIRSEEG 双模态研究,但多为分立设备实现,数据存在测量通道有限、灵敏度低、数据不同步等诸多问题。为了更好地在日常情境下探索大脑的神经电生理变化过程,发展了一种轻量型 fNIRS-EEG 双模态成像系统,实现了覆盖全脑的 fNIRS(80通道)和 EEG(32通道)的同步采集、实时传输以及结果可视化。首先通过一系列的性能评估实验验证了系统的性能:就 fNIRS 测量而言,多源并行测量模式下系统波动程度<1% ,线性度>0.99 ,可以准确探测10 mm深度下20%的波动变化;就 EEG 测量而言,系统输入参考噪声<1 μV,信噪比可达52 dB(输入信号100 μV),共模抑制比可达112 dB;就一体化测量而言,系统可实现20 Hz(fNIRS)和500 Hz(EEG)的高信效度全并行采样以及传输,并提供基于终端时钟的时间戳信息,以实现同步触发超扫描监测。进一步地,利用稳态视觉诱发实验验证了所发展系统的在体监测能力。综上,系统可以实现在同一时间标准下大脑神经电信息与血氧活动信息一体化动态采集,为日常情境脑感知和认知监测提供了新的仪器平台。

    Abstract:

    In recent years, functional nearinfrared spectroscopy (fNIRS) and electroencephalography (EEG) have been extensively employed to measure and analyze neurocognitive responses and mental states during natural and social interactions. While fNIRS-EEG bimodal fusion has shown promise, challenges remain, including limited channel counts, low sensitivity, and poor data synchronization. To address these issues and enable more effective investigation of neurophysiological dynamics in everyday scenarios, we developed a lightweight fNIRS-EEG imaging system capable of synchronized acquisition, real-time data transmission, and visualization. The system integrates 80-channel fNIRS and 32-channel EEG coverage across the whole brain. System performance was first validated through a series of benchmark tests. For fNIRS, the signal fluctuation under fully parallel measurement remained below 1%, with linearity exceeding 0.99, successfully detecting 20% signal variation at a 10 mm depth in a two-layer brain-mimicking phantom. For EEG, the system achieved a signal-to-noise ratio of 52 dB (with a 1 μV reference noise level) at an input of 100 μV, and a common-mode rejection ratio of up to 112 dB. In integrated mode, the system supports simultaneous sampling at 20 Hz (fNIRS) and 500 Hz (EEG), with timestamping based on the terminal clock to enable synchronous hyperscanning. To further demonstrate in-vivo capability, a canonical steady-state visual stimulation experiment was conducted, confirming the system′s ability to monitor neural activation. In summary, this integrated system provides a novel, real-time platform for simultaneous monitoring of brain electrical activity and hemodynamic responses, facilitating research on perception and cognition in real-world contexts.

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王语珂,朱闻睿,张丽敏,高峰,刘东远.面向神经血动力与电生理监测的一体化fNIRS-EEG成像系统[J].仪器仪表学报,2025,46(4):184-192

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  • 在线发布日期: 2025-06-23
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