In order to investigate the longrange temporal correlations (LRTC) of broadband EEG oscillation in poststroke depression (PSD) patients with unilateral hemispheric injury, Broadband EEG (0.6~46 Hz) of 18 poststroke depression patients (8 left hemispheric lesion and 10 right hemispheric lesion) and 22 poststroke nondepression patients (12 left hemispheric lesion and 10 right hemispheric lesion) in the time range of 0.2~3 s. The results show that, although the depressive symptoms is more severe in depressed patients of left lesion than right lesion, significantly decreased LRTC in depressive related brain regions only found in PSD patients with right hemispheric lesion. The results that the pathophysiology of PSD in different hemispheric damage different and support the notion that the association between poststroke depression and lesion location is complex.